|
KMID : 0960920020010010039
|
|
Dementia and Neurocognitive Disorders
2002 Volume.1 No. 1 p.39 ~ p.43
|
|
|
A Case of Alzheimer’s Disease; An Autopsy Report
|
|
Han Seol-Heui
Lee Kun-Kuk
Yang Ki-Hwa
Tjang Soun-Hoan
|
|
|
Abstract
|
|
|
|
While the clinical diagnostic accuracy of probable Alzheimer’s disease(AD) is 87-96% with a diagnostic sensitivity/specificity of 0.81-0.87, the unequivocal diagnosis of AD rests on histopathological evidence at brain autopsy and/or biopsy. We report here a 92-year-old woman whose clinical presentation suggested a far advanced Alzheimer’s disease. Formal neuropsychological evaluations were not applicable due to severe cognitive impairments. With a relatively good general physical condition she could walk with aid during her last days. No focal neutological signs were noted on a detailed examination. Brain MRI revealed a diffuse cortical atrophy with a marked reduction in the hippocampal volume. The brain obtained weighed 780g. The cerebral hemispheres examined after fixation disclosed moderately severe atrophy in prefrontal and temporal lobes. On cornal section, the hippocampus was likewise severely atrophied, the lateral ventricles were moderately dilated. On microscopic examination, there were numerous sentile plaques and neurofibrillary tangles in the neocortices, hippocampus and amyglada, compatible with advanced Alzheimer’s disease. In summary, we report the first Korean autopsy-proven case with advanced Alzheimer’s disease.
|
|
|
KEYWORD
|
|
|
Alzheimer’s disease, Brain autopsy, Senile plaques, Neurofibrillary tangles
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|